abstract：:Alkaline treatment of proteins leads to chemical changes which alter the proteins' digestibility. Severely alkali-treated casein (0.2N NaOH, 80 degrees C, 1 hour) in the diet reduces food intake and growth of young but not of adult Sprague Dawley rats. Gastrointestinal transit time is not reduced significantly in eith...

journal_title：Advances in experimental medicine and biology

authors： Possompes B,Berger J

更新日期：1986-01-01 00:00:00

abstract：:Kallikreins were localized in the human parotid gland and in the human kidney from two different aspects of the enzyme: the enzyme antigenicity and the enzyme activity. In the human parotid gland, the kallikrein antigenicity and the enzyme activity were identical in their locations in the ductal cells. In the human ki...

journal_title：Advances in experimental medicine and biology

authors： Kimura K,Moriya H

更新日期：1986-01-01 00:00:00

abstract：:The effects of ANTU-induced acute pulmonary capillary injury on lung and serum ACE functional activity and the specific accumulation of radio-labelled anti-ACE in lung were explored. Rats were injected either with ANTU or the solvent and sacrificed at various intervals up to one week after injection. All ANTU-injected...

journal_title：Advances in experimental medicine and biology

authors： McCormick JR,Moore M,Chrzanowski R,Cieplinski W

更新日期：1986-01-01 00:00:00

abstract：:We have found that apparent Ki values of some, but not all, carboxyalkyl-dipeptide inhibitors of angiotensin converting enzyme decrease as a function of incubation time. The most potent of the ACE inhibitors tested so far is RAC-X-65 (N-[1(S)-carboxy-3-carboxanilidiopropyl]-L-Ala-L-Pro). When RAC-X-65 is not preincuba...

journal_title：Advances in experimental medicine and biology

authors： Ryan JW,Chung AY,Berryer P,Murray MA,Ryan JP

更新日期：1986-01-01 00:00:00

abstract：:In this communication I have attempted to present an overview of some contributions to the understanding of the oviduct-egg interaction in amphibians. According to data from other authors, the vitelline envelope of the newly ovulated egg constitutes a barrier for the passage of spermatozoa. Our results demonstrated th...

journal_title：Advances in experimental medicine and biology

authors： Miceli DC

更新日期：1986-01-01 00:00:00

abstract：:Our current understanding of focal seizures strongly suggests a model of damage and associated synaptic reorganization that leads to periodic 'spontaneous' hyperexcitation and/or sustained firing that generates seizures. Our working model of a human epileptic focus assumes that there will often be inexcitability near ...

journal_title：Advances in experimental medicine and biology

authors： Babb TL

更新日期：1986-01-01 00:00:00

abstract：:Fertilization of urodele amphibians is physiologically polyspermic. These amphibians lack sperm entry blocking mechanisms at the egg surface, such as a cortical reaction or a membrane depolarization. Although, egg jelly is necessary for sperm capacitation, a late block to sperm entry does occur about 30 min after fert...

journal_title：Advances in experimental medicine and biology

authors： Jego P,Lerivray H,Chesnel A,Charbonneau M

更新日期：1986-01-01 00:00:00

abstract：:Kinins are potent myotropic agents acting on a variety of smooth muscle preparations: isolated arteries, veins, intestines, tracheae, urinary bladders, uteri, etc. In these tissues, kinins activate at least two different receptor types, B1 and B2. B1 and B2 receptors for kinins have been identified by measuring the or...

journal_title：Advances in experimental medicine and biology

authors： Regoli D

更新日期：1986-01-01 00:00:00

abstract：:The sea urchin fertilization envelope (FE) is formed following initial sperm-egg interaction from the egg surface vitelline envelope (VE) and the paracrystalline protein fraction (PCF), derived from cortical granules. Although mature FEs are physicochemically hardened postinsemination, a major protein fraction consist...

journal_title：Advances in experimental medicine and biology

authors： Carroll EJ Jr,Acevedo-Duncan M,Justice RW,Santiago L

更新日期：1986-01-01 00:00:00

abstract：:Calcium absorption in the large intestine was studied under physiological conditions in the rat. When 45Ca was administered directly into the caecum, the isotope was significantly absorbed. This absorption was modulated by dietary Ca and Pi as well as by the 1,25(OH) D3 status. On the other hand, calcium coming from t...

journal_title：Advances in experimental medicine and biology

authors： Ammann P,Rizzoli R,Fleisch H

更新日期：1986-01-01 00:00:00

abstract：:In healthy normotensive pregnancy, a complex functional network develops between the cardiovascular system, the volume and composition of the extracellular fluid and the renin-angiotensin system (RAS). Cardiac output and heart rate increase, but blood pressure is reduced. The kidneys increase in size and both the glom...

journal_title：Advances in experimental medicine and biology

authors： Daniels CR,Eisen V,Slater JD

更新日期：1986-01-01 00:00:00

abstract：:Two species of T-kininogen which release T-kinin (Ile-Ser-bradykinin) have been purified from plasma of rats treated with Freund's complete adjuvant. The molecular weight was estimated to be 69,000 for either T-kininogen I and II by SDS-polyacrylamide gel electrophoresis. Trypsin released one mole of T-kinin from one ...

journal_title：Advances in experimental medicine and biology

authors： Okamoto H,Greenbaum LM

更新日期：1986-01-01 00:00:00

abstract：:From wildtype mouse lymphoma cells, a clone (FURT-1A), was isolated by virtue of its resistance to 1 microM 5-fluorouracil. In comparative growth rate experiments, FURT-1A cells were also less sensitive than parental cells to the growth inhibitory effects of thymidine, deoxyguanosine, 5-fluorouridine, and arabinosylcy...

journal_title：Advances in experimental medicine and biology

authors： Aronow B,Ullman B

更新日期：1986-01-01 00:00:00

abstract：:Observation of a markedly depressed HDL-cholesterol (5 mg/dL) in a patient with familial hypercholesterolemia (FH) receiving probucol (1 g/day) and clofibrate (2 g/day) prompted a review of all cases treated by this combination at our lipid clinic. Hypoalphalipoproteinemia (HDL-C less than 15 mg/dL) developed in 19 of...

journal_title：Advances in experimental medicine and biology

authors： Davignon J,Nestruck AC,Alaupovic P,Bouthillier D

更新日期：1986-01-01 00:00:00

abstract：:In the anesthetized dog, the metabolic level of the pancreas was elevated by a secretin infusion (1.2 U/kg/hr iv), displaying a metabolic control of tissue oxygenation and blood flow. Question was raised how this system would response to a decrease in O2 supply, as induced by increasing doses of vasopressin (2-131 mU/...

journal_title：Advances in experimental medicine and biology

authors： Beijer HJ,Charbon GA,Woerlee M

更新日期：1986-01-01 00:00:00

abstract：:In order to investigate the spinal cord surface PO2 (sPO2) reaction to hypovolemic hypotension, nine female pigs (25 kg bw) were premedicated, anesthetized, intubated and artificially ventilated with N2O:O2 = 3:1. Following laminectomy from L3 to L5, sPO2 was measured on the dorsal side of the exposed spinal cord usin...

journal_title：Advances in experimental medicine and biology

authors： Metzger H,Hartmann M,Wadouh F

更新日期：1986-01-01 00:00:00

abstract：:The ability of polyphenolic compounds to form insoluble complexes with other macro-molecules such as proteins has long been associated with the observed reduction in nutritive value resulting from their inclusion in animal diets. Naturally occurring polyphenols, and in particular condensed tannins isolated from variou...

journal_title：Advances in experimental medicine and biology

authors： Griffiths DW

更新日期：1986-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 receptors are cytosoluble proteins detectable in a variety of tissues responsive to 1,25(OH)2D3. They are DNA binding-proteins analogous to other steroid receptors and it is this functional property which is likely involved in the activation of hormone-sensitive genes. Utilizing 1,25(OH)2D3 an...

journal_title：Advances in experimental medicine and biology

authors： Pike JW,Allegretto EA,Kelly MA,Donaldson CA,Marion SL,Mangelsdorf DJ,Haussler MR

更新日期：1986-01-01 00:00:00

abstract：:Proteinase inhibitor proteins in the families Solanaceae, Leguminosae and Graminae are stored in seeds and tubers and are also found to accumulate in leaves in response to pest attacks. The isolation of the proteinase Inhibitor I cDNA and its gene from tomato has provided information concerning proteinase inhibitor sy...

journal_title：Advances in experimental medicine and biology

authors： Brown WE,Graham JS,Lee JS,Ryan CA

更新日期：1986-01-01 00:00:00

abstract：:The effect of caloric intake on tumor growth has been recognized for over 70 years. Inhibition of tumor growth depends primarily on the extent of caloric restriction, but tumor type, animal strain, and dietary composition all exert some influence. Caloric restriction is most effective when maintained during both initi...

journal_title：Advances in experimental medicine and biology

authors： Kritchevsky D,Klurfeld DM

更新日期：1986-01-01 00:00:00

abstract：:The classic function of 1,25-dihydroxyvitamin D3, the hormonally active form of vitamin D, is the maintenance of normal levels of calcium and phosphorus in the blood. 1,25-Dihydroxyvitamin D3 binds to a specific receptor protein and exerts its biologic action by a mechanism analogous to that proposed for other steroid...

journal_title：Advances in experimental medicine and biology

authors： DeLuca HF,Ostrem V

更新日期：1986-01-01 00:00:00

abstract：:Speract (Gly-Phe-Asp-Leu-Asn-Gly-Gly-Gly-Val-Gly), a peptide obtained from the culture medium of Strongylocentrotus purpuratus eggs, stimulates the respiration and motility of S. purpuratus spermatozoa under appropriate conditions. Resact (Cys-Val-Thr-Gly-Ala-Pro-Gly-Cys-Val-Gly-Gly-Gly-Arg-LeuNH2), a peptide obtained...

journal_title：Advances in experimental medicine and biology

authors： Garbers DL,Bentley JK,Dangott LJ,Ramarao CS,Shimomura H,Suzuki N,Thorpe D

更新日期：1986-01-01 00:00:00

abstract：:Extracellular free sodium (Na+)o and calcium (Ca2+)o concentration changes were measured in the rat motor cortex, using ion-selective microelectrodes. During ionophoretic applications of excitatory amino acids, decreases in (Na2+)o and in (Ca2+)o were observed. Ca2+ signals were not or very little modified by applicat...

journal_title：Advances in experimental medicine and biology

authors： Pumain R,Louvel J,Kurcewicz I

更新日期：1986-01-01 00:00:00

abstract：:Screening of chromogenic peptide substrates have shown that FXIIa readily splits substrates of D-Pro-Phe-Arg-pNA (S-2302) and -Gly-Arg-pNA (e.g. S-2222) types. The latter type is preferred in a system where kallikrein is present. By using the substrate S-2222 a method for the determination of beta FXIIa inhibitors has...

journal_title：Advances in experimental medicine and biology

authors： Friberger P,Aurell L,Rees W,Gallimore MJ

更新日期：1986-01-01 00:00:00

abstract：:In order to clarify the significance of the renal kallikrein(KAL)-kinin(KIN) system and prostaglandins (PG) in exaggerated natriuresis in essential hypertensives, the effect of acute sodium load on urinary KAL, KIN, PG, and renal water and sodium handling were investigated in normotensives (NT) and patients with essen...

journal_title：Advances in experimental medicine and biology

authors： Nishimiya T,Shimamoto K,Tanaka S,Ura N,Mita T,Nakagawa M,Maeda T,Yamaguchi Y,Masuca A,Iimura O

更新日期：1986-01-01 00:00:00

abstract：:The limited proteolysis of human HMW kininogen by plasma kallikrein has been studied. Kallikrein liberated bradykinin from HMW kininogen (Mr 114 kDa) and generated a two-chain molecule with a heavy chain of Mr 63 kDa and a light chain of Mr 58 kDa interconnected via a single disulfide bridge. As proteolysis proceeded,...

journal_title：Advances in experimental medicine and biology

authors： Müller-Esterl W,Hock H,Rauth G,Kellermann J,Lottspeich F,Henschen A

更新日期：1986-01-01 00:00:00

abstract：:The first purpose of this work was to obtain direct evidence that tissue kallikreins cleave arginyl bonds when the leaving group is Arg-Val, and on the contrary, do not split them when it is Arg-Pro; the second aim was to ascertain whether this specificity could be used as a criterion, for characterizing tissue kallik...

journal_title：Advances in experimental medicine and biology

authors： Prado ES,Juliano L,Araújo-Viel MS,Juliano MA

更新日期：1986-01-01 00:00:00

abstract：:A kininogenase resembling glandular kallikrein was partially purified from vascular tissue and characterized. Saline perfused rat tail arteries and veins were homogenized in 0.25 M sucrose containing 10 mM Tris-HCl (pH 7.4). The homogenate was centrifuged at 105,000 X g for 60 min and a vascular kininogenase was purif...

journal_title：Advances in experimental medicine and biology

authors： Nolly H,Scicli AG,Scicli G,Lama MC,Guercio AM,Carretero OA

更新日期：1986-01-01 00:00:00

abstract：:The gene coding for the surface spike protein gp195 of TGEV has been cloned and expressed in E. coli in the form of fusion proteins. These proteins were isolated and used to immunize laboratory animals. All animals developed antibodies cross-reacting with the TGEV virion but failed to neutralize the virus. The entire ...

journal_title：Advances in experimental medicine and biology

authors： Hu S,Bruszewski J,Smalling R,Browne JK

更新日期：1985-01-01 00:00:00

abstract：:Blood flow of human mammary carcinomas heterotransplanted into immune- deficient rnu/rnu-rats is low. It decreases further with increasing tumor wet weight, the mean value being comparable to that of mammary carcinomas in patients. The O2 consumption rate of the heterotransplanted tumors decreases with increasing tumo...

journal_title：Advances in experimental medicine and biology

authors： Dave S,Kallinowski F,Vaupel P

更新日期：1985-01-01 00:00:00

abstract：:From these liver perfusions with Hb and Hb/HbNFPLP solutions the following conclusions can be drawn: In spite of the chemical modification of the hemoglobin molecule, no rheological differences are seen. All parameters measured were sensitive to hypoxia induced by a decrease in perfusion flow rate. The NFPLP-induced d...

journal_title：Advances in experimental medicine and biology

authors： van der Plas J,Bleeker WK,de Vries-van Rossen A,van Hamersveld A,Rigter G,Loos JA,Bakker JC

更新日期：1985-01-01 00:00:00

abstract：:In order to investigate the changes in tissue oxygen and the efficiency of the collateral circulation in the different regions of the spinal cord (SC) during aortic occlusion, surface PO2 (sPO2) was measured on the exposed SC in the pig in the lumbar (L3-5) as well as in the thoracic (Th6-8) parts before, during and a...

journal_title：Advances in experimental medicine and biology

authors： Wadouh F,Hartmann M,Arndt CF,Metzger H,Borst HG

更新日期：1985-01-01 00:00:00

abstract：:The role of adjuvanticity in the modification of the immune induction was studied by separate application of antigen and adjuvant in mice. An antigen specific plaque forming cell (PFC) test and a delayed type hypersensitivity (DTH) assay were used for these studies. Antigen (SRBC) and adjuvant were applied separately ...

journal_title：Advances in experimental medicine and biology

authors： Bianchi AT,van der Heijden PJ,Bokhout BA

更新日期：1985-01-01 00:00:00

abstract：:We have reviewed the biologic characteristics, immune responses, and diverse array of diseases occurring from Epstein-Barr virus infections in immune deficient patients. We have summarized possible roles of the virus in the risk groups for AIDS. Data is convincing that EBV is responsible for some of the cases of lymph...

journal_title：Advances in experimental medicine and biology

authors： Purtilo DT,Kipscomb H,Krueger G,Sonnabend J,Casareale D,Volsky DJ

更新日期：1985-01-01 00:00:00

abstract：:Soluble natural killer cytotoxic factors (NKCF) have been detected in the supernatant of normal mouse, rat, and human lymphocytes stimulated in vitro for 1 to 3 days in serum-free medium. Stimulation of large granular lymphocytes (LGL) with NK-sensitive targets or mitogens has resulted in high levels of NKCF productio...

journal_title：Advances in experimental medicine and biology

authors： Ortaldo JR,Blanca I,Herberman RB

更新日期：1985-01-01 00:00:00

abstract：:Cell and DNA replicative potentials were studied in 10 strains of skin fibroblasts from unrelated patients with the Werner syndrome (WS) and in a progeric CRL 1277 strain. The lifespans of all WS strains and of CRL 1277 cells are greatly abbreviated in vitro, due to large fractions of non-cycling cells and the basic p...

journal_title：Advances in experimental medicine and biology

authors： Fujiwara Y,Kano Y,Ichihashi M,Nakao Y,Matsumura T

更新日期：1985-01-01 00:00:00

abstract：:The passage of CO2 through water layers is attended by concurrent transport of (bi)carbonate. Since both bicarbonate and carbonate are charged molecules, their diffusion may evoke electric potentials and thus there will be interaction with all other ions present in the solution. Such effects have been described in the...

journal_title：Advances in experimental medicine and biology

authors： Hoofd L,van der Ven W

更新日期：1985-01-01 00:00:00

abstract：:Mitochondrial ATPase and adenylate kinase activity of hepatoma cells were inhibited by hematoporphyrin derivative (HPD) followed by photoirradiation. Inhibition of ATPase activity was a dose- and time-related event. Malonaldehyde (MDA) content of mitochondrial membranes was markedly increased by HPD plus light. The co...

journal_title：Advances in experimental medicine and biology

authors： Fu NW,Yeh SY,Chang C,Zhao XH,Chang LS

更新日期：1985-01-01 00:00:00

abstract：:The rotaviruses are important medical and veterinary pathogens that cause acute diarrheal disease in children and in the young of most mammalian and avian species. The successful development of a rotavirus vaccine should significantly reduce worldwide infant morbidity and mortality and economic losses and increase foo...

journal_title：Advances in experimental medicine and biology

authors： Estes MK,Graham DY

更新日期：1985-01-01 00:00:00

abstract：:Crithidia fasciculata DNA topoisomerase (22) has been purified to near homogeneity from trypanosomatid cell extracts. The purified enzyme catalyzes the reversible interconversion of monomeric duplex DNA circles and catenanes in an ATP dependent reaction. Reversible catenane formation is affected by the ionic strength ...

journal_title：Advances in experimental medicine and biology

authors： Shlomai J,Zadok A,Frank D

更新日期：1984-01-01 00:00:00